One Milestone
Studio Gang and Henning Larsen Complete Breakthrough Properties’ One Milestone
Final building in first phase of Tishman Speyer and Harvard Allston Land Company’s Enterprise Research Campus establishes a new destination for Greater Boston’s scientific community.
Henning Larsen, the international studio working across architecture and urbanism, and Studio Gang, the international architecture and urban design firm led by Jeanne Gang, announced the completion of Breakthrough Properties’ One Milestone, a new hub for advancing science and research.
Featuring distinct designs from each firm, One Milestone completes the first phase of Tishman Speyer and the Harvard Allston Land Company’s Enterprise Research Campus, a new mixed-use development in Allston.
Developed by Breakthrough Properties, a joint venture of Tishman Speyer and Bellco Capital, One Milestone is already attracting world-leading occupiers such as Roche’s Genentech. The newly completed complex was recently awarded the 2026 Fitwel Best in Building Health Award after achieving Fitwel 2-star certification and is pursuing LEED Gold certification.
One Milestone creates a welcoming, flexible environment that encourages interaction, experimentation, and contemplation. Located on the southwest end of the Enterprise Research Campus, the two-building complex is composed of One Milestone East, designed by Henning Larsen, and One Milestone West, designed by Studio Gang.
Designed by Henning Larsen, a transparent three-storey atrium links the two buildings and enables interaction at every scale, providing amenities and collaboration spaces for occupants across both sides of the complex. Arrowstreet served as Architect of Record and Sustainability Consultant for One Milestone, translating the design teams’ vision into a high-performance life science environment.
As curated by the Breakthrough Art Program, the building features original works by artists whose practices explore the broad field of life sciences and foster collaboration across disciplines, integrating insights from science, technology, and the humanities to inspire interdisciplinary thinking and discovery. These include artworks by Ai Weiwei, Mungo Thomson, Eamon Ore-Giron, Lyès-Olivier Sidhoum, Ernesto Neto, Alexandre da Cunha, Goshka Macuga, Noémie Goudal, Jan-Ole Schiemann, and Analia Saban.
One Milestone marks Henning Larsen and Studio Gang’s latest collaboration on the Enterprise Research Campus, which began in 2019 with their co-design of a strategic framework plan for creating a vibrant and inclusive public realm that brings the campus and surrounding community together.
The building is part of the first phase of the Enterprise Research Campus development effort led by the Harvard Allston Land Company and Tishman Speyer. The first phase features four new buildings, all designed by internationally renowned architecture practices, connected by Allstonway, a SCAPE-designed network of public green spaces anchoring the district.
In addition to One Milestone, Enterprise Research Campus buildings include: The Atlas, a boutique hotel designed by Marlon Blackwell Architects that opened earlier this year; the David Rubenstein Treehouse, a new conference facility designed by Studio Gang that opened in October 2025; and Verra, a 343-unit apartment building designed by MVRDV that began welcoming residents last year.
One Milestone East
Anchoring the southeastern point of Allstonway, the Henning Larsen-designed One Milestone East represents a new vision for lab design. The nine-storey, 265,000-square-foot life science building combines flexible laboratories and offices with a range of shared indoor and outdoor tenant amenities, arranged in a characteristic cascading design informed by access to daylight and nature.
An efficient L-shaped floor plan separates the laboratory section from flexible office spaces. One Milestone East houses fully customizable floor plates ranging from 34,000 to 36,000 square feet, as well as StudioLabs, a serviced and equipped laboratory and office concept by Breakthrough Properties, designed to offer private, turnkey suites to growing life science companies.
The building has already attracted a high-profile anchor tenant, with Roche’s Genentech committing to 100,000 square feet to establish a new innovation centre focused on Cardiovascular, Renal, and Metabolism discovery, as well as AI and data science initiatives. This is a powerful demonstration of One Milestone East’s ability to attract world-leading science to the Enterprise Research Campus.
“Connectivity is our design driver. The cascading terraces bring the character of Allstonway upward through the building, giving researchers at every floor a direct relationship to the outdoors and the broader life of the campus. Floor-to-ceiling glazing and landscaped outdoor spaces ensure that the boundary between the controlled laboratory environment and the urban landscape around it stays deliberately, productively blurred. Working in parallel with our colleagues at Studio Gang on One Milestone West, we were able to ensure the two buildings speak to each other — each distinct in character, but united in their commitment to the street and the people who animate it,” said Daniel Baumann, Design Director, Americas, Henning Larsen.
At ground level, the building engages directly with Allstonway, its cascading form creating sheltered spaces that invite researchers and visitors to linger, meet, and socialize at the building’s edges. The façade’s differentiated massing and scalloped cladding play with light and shadow throughout the day, paying homage to the historic architecture of the nearby Harvard Business School through a contemporary reinterpretation of its fine grain and saturated earthen tones.
Landscaped outdoor spaces invite researchers to step outside the controlled laboratory environment for meetings, events, or informal collaboration, while lush plantings reinforce the building’s connection to the surrounding landscape. Full-height glazing and high-performance glass maximize daylight penetration while minimizing heat transmittance, contributing to a 40% reduction in energy consumption from baseline.
The building’s massing serves as a visual and acoustic barrier from the District Energy Facility for the residential buildings north of Allstonway. One Milestone East demonstrates that high-performance life science facilities can be both productive environments for world-leading research and active contributors to the life of the city around them.
One Milestone East Project Team
Architect: Henning Larsen
Daniel Baumann, Partner in Charge and Design Director
Sara Rubenstein, Principal
Veronica Varela, Project Manager
Sebastian Hofmeister, Lead Designer
One Milestone West
The design of the 245,000-square-foot One Milestone West features a transparent façade and carved form that helps foster connections between indoors and outdoors. Composed of long bands of solid zones interspersed with glazing, whose horizontality creates a dynamic contrast with the vertically articulated design of One Milestone East, the strata-like façade brings natural light into the building.
As light moves across it, the façade’s panels shift subtly in colour, establishing a dynamic presence on the campus. At ground level, the building subtly steps back to create sheltered areas for dining and socialising, activating the building’s edges and Allstonway.
The upper floors are dedicated to flexible laboratories and workspaces that support a range of activities, from quiet areas for focused research to common areas for meeting and discussion. Carving is kept to a minimum on the south side to maintain optimal depth for laboratory use, while on the north, the stepped form creates outdoor terraces that offer access to fresh air and expansive views.
“It has been a fascinating and rewarding process to create the design vision for the Enterprise Research Campus with Henning Larsen, and to bring the district to life through the architecture of One Milestone and the David Rubenstein Treehouse at Harvard University,” said Weston Walker, Design Principal and Partner at Studio Gang.
“The design of One Milestone West is carefully sculpted in response to the programme and its context. Users will enjoy flexible workspaces, generous terraces, and panoramic views. Neighbours will enjoy the building’s dynamic form, calibrated to enhance sunlight along Allstonway and to create a welcoming gesture along Trotting Avenue.”
The building’s design demonstrates that laboratories can not only be welcoming and engaging workspaces, but also integral to the development of a more sustainable civic realm. One Milestone West’s façade is carefully tuned to balance thermal performance year-round, while large opaque areas make the building more detectable to birds and reduce potential collisions.
Its carved form allows sunlight to reach the public green spaces below, where bioswales and retention tanks are integrated throughout the revitalised landscape. The use of low-carbon concrete, insulation, and steel reduces One Milestone West’s embodied carbon, and nearly half the materials used are Red List Free-compliant.
“One Milestone required an unusually integrated approach, balancing advanced laboratory requirements, complex technical coordination, and measurable performance outcomes across two distinct buildings,” said Amy Korté, President of Arrowstreet.
“By establishing performance priorities early and carrying them through design and construction, the project was able to advance carbon reduction, resilience, wellness, and healthy materials strategies in a deeply integrated way,” said Kate Bubriski, Director of Building Performance at Arrowstreet.
“The result is a life science environment that supports rigorous research while strengthening the everyday human connection to daylight, landscape, and place.”
One Milestone West Project Team
Design Architect: Studio Gang, New York
Jeanne Gang, Lead Designer and Founding Partner
Wes Walker, Design Principal and Partner
Bryan Scheib, Design Director
Wei-Ju Lai, Senior Project Leader
